Mito 101

MITO 101: A Primer for Physicians and Patients is a compilation of information intended to familiarize general practitioners and families alike with the  most common problems raised by mitochondrial diseases.

Note: MITO 101 is merely to be used as a tool. It is not meant to be a substitute for professional advice and services rendered by qualified doctors, allied medical personnel, and other professional services. The responsibility for any use of this information, or for proper medical treatment, rests with you and your physician.

Introduction Videos

Diagnosis

  • Mitochondrial Disease: A Practical Approach for Primary Care Physicians– Richard Haas, Sumit Parikh, Marni J. Falk, Russell Saneto, Nicole Wolfe, Niklas Darin, Bruce H. Cohen. (Reprinted with permission from the Journal of the American Academy of Pediatrics, Pediatrics 2007; 120;1326-1333,DOI:10.1542/peds.2007-0391
  • The In-Depth Evaluation of Mitochondrial Diseases– Richard Haas, Sumit Parikh, Marni J. Falk, Russell Saneto, Nicole I. Wolfe, Niklas Darin, Lee-Jun Wong. Reprinted with permission from Elsevier, article in press, R.H. Haas et.el., The In-Depth Evaluation of Suspected Mitochondrial Disease, Mol Genet.Metab (2008), DOI:10.1016/j.ymgme.2007.11018
  • Dysautonomia – Salvatore DiMauro, MD and Bruce H. Cohen, MD
  • Munchausen by Proxy -Also known as Medical Child Abuse. The following information was extracted from a 2011 symposium talk by Sumit Parikh, MD and other experts. Additional comments were provided by Drs. Russell Saneto and Mark Tarnopolsky

Treatment

  • Evidence Based Medicine in Mitochondrial Treatment– Bruce Cohen, MD, Cleveland Clinic
  • Exercise and Prevention – Mark A. Tarnopolsky, MD, PhD, FRCP, Professor of Pediatrics and Medicine, Neuromuscular and Neurometabolic Disease Clinic, McMaster University Medical Center, Hamilton, Ontario, Canada
  • Supplements and Nutrition – Mark A. Tarnopolsky, MD, PhD, FRCP, Professor of Pediatrics and Medicine, Neuromuscular and Neurometabolic Disease Clinic, McMaster University Medical Center, Hamilton, Ontario, Canada
  • HBOT – Article written for the UMDF Newsletter, Volume 12, Issue 1
  • Scientific and Pseudoscientific Therapies–  Article written for the UMDF Newsletter, Volume 12, Issue 2.  Steven G. Bassett, PhD, Associate Professor of Biology, Seton Hill University, Greensburg, PA., and Jean C. Bassett, RN, Pittsburgh, PA.
  • Therapy– Tracey J. Millhouse Flourie
  • Modern Approach to the Treatment of Mitochondrial Disease – Sumit Parikh, MD, Russell Saneto, DO, PhD,  Marni J. Falk, MD,  Irina Anselm, MD,  Bruce H. Cohen, MD, Richard Haas, MB, BChir, MRCP,  The Mitochondrial Medicine Society.

Neurology

Management

  • Anesthesia – Sandra Sirrs, MD, FRCPC and Margaret O’Riley, RN, MA (Ed), Medical Director, Adult Metabolic Diseases Clinic, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, Canada, Peter Duncam, MDFRCPC, Margaret O’Riley RN MA(ED)
  • Audiology– Patrick F. Chinnery, MBBS(hons), PhD, MRCPath, FRCP, Consultnat Neurologist, Regional Neuroscience Centre, Newcastle Upon Tyne, UK, Wellcome Trust Senior Fellow in Clinical Science, Professor of Neurogenetics, Univesity of Newcastle upon Tyne, UK.
  • Cardiology –  Neil Friedman, MB, ChB, MD, Neurological Institute, Cleveland Clinic.
  • Emergency Department Letter and Metabolic Precautions – Sumit Parikh, MD, Cleveland Clinic
  • Endocrinology– Douglas Kerr, MD, PhD, Case Western Reserve University School of Medicine. Matthew Feldt, DO, Rainbow Babies and Children’s Hospital of Cleveland
  • Gastroenterology – Amy C. Goldstein, MD, Child Neurologist, Division of Child Neurology, Children’s Hospital of Pittsburgh, Clinical Assistant Professor of Pediatrics and Neurology, University of Pittsburgh School Of Medicine
  • Hematology– James E. Thompson, MD, Assistant Member, Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, New York. Jaya Ganesh, MBBS, MD, MRCP – Assistant Professor of Pediatrics AC, Section of Biochemical Genetics, The Children’s Hospital of Philadelphia and University of Pennsylvania
  • Illness– Juan Pascual, MD, PhD, Division of Pediatric Neurology, Departments of Neurology, Physiology and Pediatrics, The University of Texas Southwestern Medical Center
  • Infections (recurrent)– Robert Hostoffer,DO,FAAP,FACOP, Assistant Professor of Pediatrics, Case Western Reserve University and Ohio University, Adjuvant Professor LECOM, Pennsylvania.  Mini Wallace, DO, FACOP, Attending Physician, Cleveland Clinic
  • Nutrition– Lynne A. Wolfe, MS, PNP, ACNP, BC, Metabolic Nurse Practitioner
  • Ophthalmology– Elias I. Traboulsi, MD, Cole Eye Institute, Cleveland Clinic
  • Palliative Care – Margaret Farrar-Laco, RN, MSN, CPNP-AC/PC.  Sarah Friebert, MD, FAAP, Haslinger Division of Pediatric Palliative Care, Akron Children’s Hospital, Akron, OH
  • Pain– Petra Kaufmann, MD, New York Presbyterian/Columbia
  • Pregnancy in Mitochondrial Disease– Dr. Helen Turnbull, Dr. Rebecca Say, Dr. Marie Smith, Dr. Victoria Nesbitt, Dr. Robert McFarland, Professor Doug Turnbull, Dr. Andrew Schaefer.
  • Psychiatry– Petra Kaufmann, MD, New York Presbyterian/Columbia
  • Pulmonology– Anastassios C. Koumbourlis, MD, MPH, Chief, Pulmonary Medicine, Schneider Children’s Hospital, Associate Profession of Clinical Pediatrics, Albert Einstein College of Medicine
  • Renal– Agnes Rotig, PhD and Patrick Niaudet, MD, INSERM U781 and Service de Nephrologie Pediatrique Necker Hospital, Universite Paris V-Rene Descartes, Paris, France

Unless otherwise noted, the above articles were written for the United Mitochondrial Disease Foundation. 

For reprint permission, contact the Communications Department at the UMDF at 888.317.8633.