• Developmental delays
• Dementia
• Neuro-psychiatric disturbances

• Migraines
• Autistic Features
• Mental retardation

• Seizures
• Atypical cerebral palsy
• Strokes

• Weakness (may be intermittent)
• Absent reflexes

• Fainting
• Neuropathic pain

• Dysautonomia - temperature instability &
  other dysautonomic problems

• Weakness
• Cramping
• Gastrointestinal problems
• Dysmotility

• Irritable bowl syndrome
• Hypotonia
• Muscle pain

• Gastroesophogeal reflux
• Dirrahea or constipation
• Pseudo-obstruction

• Renal tubular acidosis or wasting

• Cardiac conduction defects (heart blocks)

• Cardiomyopathy

• Hypoglycemia (low blood sugar)

• Liver failure

• Visual loss and blindness
• Ptosis
• Ophthalmoplegia

• Optic atrophy
• Hearing loss and deafness

• Acquired strabismus
• Retinitis pigmentosa

• Diabetes and exocrine pancreatic failure
  (inability to make digestive enzymes)

• Parathyroid failure (low calcium

• Failure to gain weight
• Fatigue

• Unexplained vomiting
• Short stature

• Respiratory problems

Think mitochondrial disease when three or more organ systems are involved