Possible Symptoms

Brain

  • Developmental delays
  • Dementia
  • Neuro-psychiatric disturbances
  • Migraines
  • Autistic Features
  • Mental retardation
  • Seizures
  • Atypical cerebral palsy
  • Strokes


Nerves


  • Weakness (may be intermittent)
  • Absent reflexes
    • Fainting
    • Neuropathic pain
      • Dysautonomia - temperature instability&
        other dysautonomic problems

      Muscles

      • Weakness
      • Cramping
      • Gastrointestinal problems
      • Dysmotility
      • Irritable bowel syndrome
      • Hypotonia
      • Muscle pain
      • Gastroesophogeal reflux
      • Diarrhea or constipation
      • Pseudo-obstruction

      Kidneys

      • Renal tubular acidosis or wasting


      Heart

      • Cardiac conduction defects (heart blocks)
      • Cardiomyopathy

      Liver

      • Hypoglycemia (low blood sugar)
      • Liver failure

      Ears & Eyes

      • Visual loss and blindness
      • Ptosis
      • Ophthalmoplegia
      • Optic atrophy
      • Hearing loss and deafness
      • Acquired strabismus
      • Retinitis pigmentosa

      Pancreas & other glands

      • Diabetes and exocrine pancreatic failure
        (inability to make digestive enzymes)
      • Parathyroid failure (low calcium)

      Systemic

      • Failure to gain weight
      • Fatigue
      • Unexplained vomiting
      • Short stature
      • Respiratory problems

      Think mitochondrial disease when three or more organ systems are involved